Anecdata, but an acquaintance of mine struggled with lifelong anorexia. Severe enough that he was hospitalized a few times. With great effort he could cling to the bottom of the "normal BMI" range, but his life was generally ruled by the eating disorder - he couldn't have meals with people, he had to do various exercise rituals.
He was an early participant in one of these psychedelic studies a few years ago. After the first treatment, he said he couldn't really tell if it had any effect. But six months later, he was totally changed - able to function almost normally.
We should exercise our usual amount of skepticism about miracle treatments, but my hope is that his experience can be replicated.
bbayles
Psychedelics open your brain up to rewiring in some way, and can be used under direction to treat a lot of things. But of course, people who didn't like the Vietnam War used them recreationally, which is why the US government made them globally illegal.
inigyou
I lost a family member to anorexia, and the only thing I really regret is that I didn't suggest that we try psychedelic therapy now that everything else had failed and things looked pretty grim. I mostly blame myself for not pushing the idea. But I am also angry at the war on drugs which has caused all use of psychoactive drugs to be associated with such taboo.
ulrikrasmussen
Psychedelics arent that far from turning your brain off and then turning it back on again
but anyone i have met that did Psychedelics more than a few times, permanently changed their brain chemistry in a way that was obvious. clearly they are doing some kind of unraveling that doesnt fully bounce back
mikert89
I attended a presentation at the maps conference in ‘23(?). The presenter said that the effect was not enduring for those on already on a path to recovery. She hypothesized that the body need nourishment and a lot of ancillary support to sustain that kind of neurological change.
(I’ll try to search for it when I have free time)
Psychedelic trips are taxing on the body and I think I agree with the hypothesis nutrients are underestimated in supporting a healthy mind in these states, from personal experience.
stephenitis
Sorry, but the answer is almost certainly no. We now have good quality data on psylocybin as a treatment for depression; at best, it's slightly more effective than existing treatments, at the cost of a small but significant increased risk side-effects (primarily severe acute anxiety and psychosis, possibly HPPD). We have less data on other psychedelics and other conditions, but none of it looks spectacular when you take into account the usual biases affecting small trials of novel treatments.
Psychedelics are likely to be a good option for some patients, it's good to have another tool in the armamentarium, but the idea that they're a revolution in psychiatry is simply no longer credible.
Disclosure: I have participated in a clinical trial of psilocybin for treatment-resistant depression and did not see any meaningful benefit.
jdietrich
We hear a lot of psilocybine lately, it cures altsheimer, people in coma awake miraculously. As long as we do not understand the workings, it reminds me of the days when radium or other nuclear substances were the cure for everything.
Mushrooms have always made me vomit... So treat anorexia with bulimia? Hmmm.
firebot
This feels like a case where Betteridge's law of headlines applies, or at least should be presumed. [Recreational Drug] solves [malady] is such a hopeful go to and has recurred countless times.
I've partaken of 'shrooms a number of times: Fun times. I've even grown them (protip - not worth the trouble. It's amazing how something that grows in literal shit is suddenly the most fragile process imaginable when you try your PFTek method, and contamination will always be ruining your process). But people keep trying to make psilocybin a magic solution, and the studies have been extremely weak if not contradictory, and these stories always lean on worthless anecdotes.
comments (10)
He was an early participant in one of these psychedelic studies a few years ago. After the first treatment, he said he couldn't really tell if it had any effect. But six months later, he was totally changed - able to function almost normally.
We should exercise our usual amount of skepticism about miracle treatments, but my hope is that his experience can be replicated.
bbayles
inigyou
ulrikrasmussen
but anyone i have met that did Psychedelics more than a few times, permanently changed their brain chemistry in a way that was obvious. clearly they are doing some kind of unraveling that doesnt fully bounce back
mikert89
(I’ll try to search for it when I have free time)
Psychedelic trips are taxing on the body and I think I agree with the hypothesis nutrients are underestimated in supporting a healthy mind in these states, from personal experience.
stephenitis
Psychedelics are likely to be a good option for some patients, it's good to have another tool in the armamentarium, but the idea that they're a revolution in psychiatry is simply no longer credible.
https://pubmed.ncbi.nlm.nih.gov/39627679/
Disclosure: I have participated in a clinical trial of psilocybin for treatment-resistant depression and did not see any meaningful benefit.
jdietrich
jhoechtl
cainxinth
firebot
I've partaken of 'shrooms a number of times: Fun times. I've even grown them (protip - not worth the trouble. It's amazing how something that grows in literal shit is suddenly the most fragile process imaginable when you try your PFTek method, and contamination will always be ruining your process). But people keep trying to make psilocybin a magic solution, and the studies have been extremely weak if not contradictory, and these stories always lean on worthless anecdotes.
llm_nerd